Mint (Peppermint)
Mentha × piperita
Common & Folk Names
- Peppermint
- Brandy Mint
- Balm Mint
- Candy Mint
- Lamb Mint
- Paparaminta
- Vilayati Pudina
Note on Spearmint: Mentha spicata (spearmint, garden mint, common mint) is a related species with milder properties, dominated by carvone rather than menthol. This monograph focuses primarily on peppermint (M. × piperita), which has stronger medicinal actions and more extensive clinical research.
Plant Family
Lamiaceae (Mint family, also called Labiatae)
Geographic Location
Peppermint is a natural hybrid (sterile cross between M. aquatica and M. spicata) native to Europe and the Middle East. It is now naturalised and cultivated worldwide in temperate regions, including extensive commercial cultivation in the United States, Europe, Asia, and Australia. It does not occur truly wild but has escaped cultivation in many areas.
Habitat
Thrives in moist, rich soils along stream banks, ditches, wet meadows, and cultivated gardens. Prefers areas with consistent moisture and partial shade, though it can tolerate full sun with adequate water. Known for its vigorous spreading habit and can become invasive in favorable conditions.
Growing Conditions
Sun: Full sun to partial shade; performs best with morning sun and afternoon shade in hot climates
Soil: Prefers moist, well-drained, rich soil with high organic matter content. pH 6.0-7.0 (slightly acidic to neutral)
Propagation: Easily propagated by root division, runners, or stem cuttings, as peppermint is a sterile hybrid and does not produce viable seed. Plant cuttings or divisions in spring after last frost
Care: Requires consistent moisture–do not allow to dry out completely. Benefits from containment (in pots or buried barriers) to prevent aggressive spreading. Cut back after flowering to encourage fresh growth. Divide plants every 2-3 years to maintain vigor. Hardy in USDA zones 3-11
Invasiveness Warning: Peppermint spreads vigorously via underground rhizomes and can quickly dominate garden spaces. Always grow in containers or with root barriers unless you want it to spread
NZ Planting Calendar
Propagation (division): Spring (September–November) or autumn (March–May) – divide established clumps
Propagation (cuttings): Summer (December–February) – stem cuttings root easily
Planting: Spring (September–November) or autumn (March–May)
Flowering: December–March (summer) – small purple/white flowers
Harvest (leaves): Year-round; best before flowering for maximum oil content
Note: Not native to NZ; can become invasive; contains in pots or controlled areas; dies back in winter
Harvesting Guidelines
Harvest leaves just before flowering when essential oil content is at its peak. The best time is mid-morning after dew has evaporated but before the heat of the day. Cut stems 5-10 cm above ground level to encourage regrowth. Can harvest multiple times per season (typically 2-3 cuttings). For maximum oil content, harvest in mid to late summer when plants are in full vegetative growth or just beginning to flower.
Parts Used
- Leaves (primary medicinal part)
- Flowering tops
- Essential oil (steam-distilled from leaves and stems)
Constituents & their Actions
Peppermint contains a complex array of bioactive compounds that contribute to its distinctive cooling sensation and therapeutic properties. The essential oil composition can vary significantly based on chemotype, growing conditions, and harvest timing.
Essential Oils (Volatile Oils):
Peppermint essential oil comprises 0.5-4% of the fresh plant and contains primarily monoterpenes. The composition is dominated by menthol and related compounds. Some of the main volatile constituents are:
- L-Menthol (30-55%, typically 35-45%)
- Menthone (14-32%)
- Menthyl acetate (3-10%)
- 1,8-Cineole/Eucalyptol (3-12%)
- Isomenthone (2-10%)
- Menthofuran (1-9%)
- Limonene (1-7%)
- β-Caryophyllene (sesquiterpene, 2-4%)
- β-Pinene (1-3%)
- α-Pinene (1-2%)
The main actions of these essential oils are:
- Powerful antispasmodic (smooth muscle relaxation)
- Cooling and analgesic sensation
- Carminative (gas-relieving)
- Antimicrobial (broad-spectrum)
- Local anesthetic effects
Phenolic Compounds:
These polyphenolic constituents provide antioxidant, anti-inflammatory, and antimicrobial support. Some of the main phenolic compounds in peppermint are:
- Rosmarinic acid (major phenolic acid, 1.7-7.3% of dry weight)
- Eriocitrin (flavanone glycoside)
- Luteolin-7-O-rutinoside
- Luteolin-7-O-glucuronide
- Hesperidin
- Caffeic acid
The main actions of these phenolic compounds are:
- Potent antioxidant activity
- Anti-inflammatory (multiple pathways)
- Antimicrobial support
- Neuroprotective properties
Flavonoids:
These compounds contribute to antioxidant and anti-inflammatory actions. Some of the main flavonoids in peppermint are:
- Luteolin and luteolin glycosides
- Quercetin
- Kaempferol
- Diosmin
The main actions of these flavonoids are:
- Antioxidant (free radical scavenging)
- Anti-inflammatory
- Vascular support
- Hepatoprotective
Actions with Mechanisms
Antispasmodic (Gastrointestinal Smooth Muscle Relaxation):
L-menthol, the primary active constituent in peppermint oil, blocks voltage-dependent L-type calcium channels in intestinal smooth muscle cells, which in turn prevents calcium influx required for muscle contraction and induces direct smooth muscle relaxation. This calcium channel antagonist activity produces powerful antispasmodic effects throughout the gastrointestinal tract, which in turn reduces intestinal cramping, pain, and spasm. Additionally, menthol modulates the enteric nervous system through effects on various receptors, which in turn coordinates relaxation of the gut wall and normalises gastrointestinal motility. Clinical studies demonstrate this mechanism effectively reduces abdominal pain and cramping in irritable bowel syndrome (IBS).
Visceral Analgesic (Pain Relief):
Menthol activates TRPM8 (transient receptor potential melastatin 8) receptors, cold-sensitive ion channels highly expressed in sensory neurons of the gastrointestinal tract, which in turn triggers endogenous opioid-dependent analgesic pathways involving κ-opioid receptors. This TRPM8 activation modulates visceral pain perception, which in turn provides relief from abdominal pain without systemic opioid effects. The analgesic effects are rapid (noticeable within 24 hours) and sustained with continued use. The activation of TRPM8 also creates the characteristic cooling sensation, which in turn provides a subjective sense of relief and comfort.
Cooling Sensation:
Menthol binds specifically to TRPM8 receptors in sensory neurons using a “grab and stand” mechanism–the hydroxyl group “grabs” specific amino acids (R842) while the isopropyl group “stands” on hydrophobic residues (I846, L843), which in turn activates these cold-sensitive channels even at normal body temperature. This creates a neurological “phantom” cooling sensation without actually changing tissue temperature, which in turn provides a perceived cooling relief that can reduce pain perception and provide comfort. This cooling effect is concentration-dependent, with moderate concentrations (10-640 mM) producing pleasant coolness.
Carminative (Gas-Relieving):
The smooth muscle relaxation induced by menthol’s calcium channel blockade extends to the entire gastrointestinal tract including the lower esophageal sphincter and intestinal wall, which in turn allows trapped gas to pass more easily and reduces bloating and distention. Peppermint oil facilitates the expulsion of gas through both belching and flatulence, which in turn provides relief from uncomfortable abdominal distention and pressure. The reduction in smooth muscle tension throughout the gut, which in turn prevents gas accumulation and promotes normal peristaltic movement of intestinal contents.
Antimicrobial (Broad-Spectrum):
Menthol and menthone disrupt bacterial and fungal cell membranes due to their hydrophobic properties, which in turn causes leakage of cellular contents, disruption of metabolic processes, and cell death. The essential oil demonstrates activity against both Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis, Streptococcus species) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella species, Klebsiella pneumoniae), which in turn provides broad-spectrum protection against gastrointestinal and respiratory pathogens. The oil also shows antifungal activity against Candida albicans and Aspergillus species. Minimum inhibitory concentrations (MIC) range from 0.3-5 mg/mL depending on the microorganism, with C. albicans being particularly sensitive.
Anti-inflammatory:
Rosmarinic acid and flavonoids inhibit pro-inflammatory enzymes (COX-2, lipoxygenase) and reduce production of inflammatory cytokines including TNF-α and IL-6, which in turn decreases local and systemic inflammation. Peppermint extracts modulate immune cell activity and reduce inflammatory mediators, which in turn supports resolution of inflamed tissues in the gut, airways, and skin. The phenolic compounds also stabilise cell membranes and inhibit degranulation of mast cells, which in turn reduces allergic and inflammatory responses.
Antioxidant:
The high phenolic content, particularly rosmarinic acid and flavonoids, provides potent free radical scavenging activity through direct electron donation, which in turn neutralises reactive oxygen species (ROS) and prevents oxidative damage to cellular lipids, proteins, and DNA. The antioxidant activity measured in chemical assays (DPPH, ABTS) correlates with total phenolic content, which in turn protects tissues from oxidative stress during inflammation or infection. Eriocitrin, a flavonoid specific to peppermint, shows particularly powerful antioxidant effects in animal models.
Choleretic (Bile Flow Stimulation):
Peppermint oil stimulates bile secretion from the liver and promotes bile flow from the gallbladder, which in turn enhances fat digestion and supports liver function. The relaxation of the sphincter of Oddi facilitates bile release into the intestine, which in turn improves digestion of dietary fats. This action supports digestive function, particularly after fatty meals, though it requires caution in people with gallstones or bile duct obstruction.
Cognitive Enhancement and Alertness:
The aroma of peppermint essential oil has been shown to improve memory, attention, and alertness through modulation of neurotransmitter systems and increased cerebral blood flow, which in turn enhances cognitive performance and reduces mental fatigue. Inhalation of peppermint vapor activates the olfactory system and limbic brain regions, which in turn influences mood, arousal, and cognitive function. Studies show improved performance on memory tasks and reduced reaction times following peppermint aromatherapy.
Main Use
Peppermint’s primary medicinal use is for digestive complaints, particularly irritable bowel syndrome (IBS), where enteric-coated peppermint oil capsules have become a recognised evidence-based treatment. Clinical trials demonstrate significant reduction in IBS symptoms including abdominal pain, bloating, and altered bowel habits, with response rates of 40-75% improvement compared to 24-38% with placebo. The enteric-coating is essential to deliver the oil to the small intestine and colon, preventing premature release in the stomach that can cause heartburn.
Beyond IBS, peppermint is widely used for indigestion, nausea, flatulence, and abdominal cramping from various causes. The tea provides quick relief for upset stomach, excessive gas, and digestive discomfort, working within minutes to hours. For headaches, particularly tension headaches, topical application of diluted peppermint essential oil to the temples and forehead provides cooling relief through TRPM8 activation and local analgesic effects.
Peppermint is also valued for respiratory congestion, where the menthol vapor acts as a decongestant and expectorant. Steam inhalations or topical chest rubs help open airways and ease breathing. The antimicrobial properties support its traditional use for minor infections and as a gargle for sore throat or mouth inflammation.
In aromatherapy, peppermint essential oil is used to enhance alertness, improve concentration, reduce mental fatigue, and provide an uplifting, energising effect. The distinctive cooling, refreshing scent has made it ubiquitous in oral care products, where it provides antimicrobial benefits alongside the pleasant flavor and breath-freshening effects.
Preparations
Tea/Infusion: 1-2 teaspoons (1-3 grams) of dried leaves per cup of boiling water. Cover and steep for 5-10 minutes to preserve volatile oils. Drink up to three times daily between meals for digestive support. Best taken 30-60 minutes before meals for optimal digestive benefit
Tincture: (1:5 in 40-60% alcohol). Take 2-4 mL (40-80 drops), 2-3 times daily. Can be taken in a small amount of water. Less commonly used than tea or enteric-coated oil
Enteric-Coated Peppermint Oil Capsules: 0.2-0.4 mL (180-200 mg) peppermint oil per capsule, typically standardised to contain 90 mg oil with 41.5 mg free L-menthol. Take 1-2 capsules 2-3 times daily, 30-60 minutes before meals. Enteric coating is essential to prevent gastric irritation and ensure delivery to intestines. This is the preferred form for IBS treatment
Essential Oil (Topical): Dilute 2-5% in carrier oil (2-5 drops in 1 teaspoon/5 mL carrier oil). Apply to temples for headache, to abdomen (in circles, clockwise) for digestive discomfort, or to chest for respiratory congestion. Never apply undiluted to skin
Essential Oil (Aromatherapy): Add 3-5 drops to diffuser for mental alertness and respiratory support. Inhale directly from bottle for quick relief of nausea or mental fog
Steam Inhalation: Add 3-5 drops essential oil or large handful of fresh/dried leaves to bowl of hot water. Drape towel over head and inhale steam for 5-10 minutes for nasal and chest congestion
Dosage
Dried Leaf (Tea): 1-2 teaspoons (1-3 grams) per cup, steeped 5-10 minutes, 2-3 times daily
Tincture (1:5, 40-60% alcohol): 2-4 mL (40-80 drops), 2-3 times daily
Enteric-Coated Peppermint Oil: 0.2-0.4 mL (180-200 mg per capsule, standardised to ~90 mg oil with ~41.5 mg L-menthol), 1-2 capsules 2-3 times daily before meals. Typical course is 2-4 weeks, though longer use is generally safe
Essential Oil (Topical): 2-5% dilution (2-5 drops per 5 mL carrier oil). Apply as needed, up to 3-4 times daily
Essential Oil (Aromatherapy): 3-5 drops in diffuser or for direct inhalation as needed
Safety & Drug Interactions
Peppermint leaf tea and properly diluted essential oil are generally safe for most adults when used as directed. Peppermint is classified as “Generally Recognised As Safe” (GRAS) by the FDA for food use.
Gastrointestinal Considerations: Peppermint can relax the lower esophageal sphincter, potentially worsening gastroesophageal reflux disease (GERD) or heartburn. People with active acid reflux, hiatal hernia, or severe GERD should use caution with peppermint tea and avoid non-enteric-coated peppermint oil. Enteric-coated capsules minimise this effect by releasing oil in the intestines rather than the stomach.
Gallbladder and Bile Duct Concerns: Because peppermint stimulates bile flow, it is not recommended for people with gallstones, bile duct obstruction, or gallbladder inflammation (cholecystitis). The increased bile flow could potentially trigger gallbladder attacks or worsen obstruction.
Pregnancy and Lactation: Peppermint leaf tea in normal dietary amounts (1-2 cups daily) is generally considered safe during pregnancy. However, larger medicinal doses and concentrated essential oil (either topically or internally) should be avoided during pregnancy as there are traditional concerns about potential uterine stimulation, though evidence is limited. Some sources suggest peppermint may reduce milk supply in nursing mothers, so lactating women should use moderately and monitor for any reduction in milk production.
Children: Peppermint tea in small amounts is generally safe for children over age 8. However, concentrated peppermint oil products (including topical applications near the face) should not be used in infants or young children as menthol can cause respiratory distress, laryngospasm, or bronchospasm in susceptible individuals. Never apply peppermint oil to or near the face of infants or young children.
Allergic Reactions: Although uncommon, allergic reactions can occur, including contact dermatitis from topical use, oral allergic reactions, headache, flushing, or skin rash. People with known allergies to other Lamiaceae family plants (basil, oregano, lavender) should use caution.
Essential Oil Cautions: Undiluted peppermint essential oil should never be applied to skin or ingested. Internal use of non-enteric-coated oil can cause severe heartburn, oral irritation, and gastrointestinal upset. High doses or prolonged use of menthol can potentially cause central nervous system effects including ataxia, muscle tremor, or in extreme cases, seizures (though this is rare at normal therapeutic doses). Topical application near eyes, mucous membranes, or broken skin should be avoided.
Drug Interactions: Peppermint may interact with several medications:
- Cyclosporine (immunosuppressant): Peppermint oil may significantly increase blood levels of cyclosporine, potentially leading to toxicity. Avoid concurrent use
- Medications Metabolised by CYP450 Enzymes: Peppermint oil may affect liver enzymes that metabolise drugs, particularly CYP3A4 and CYP1A2, potentially altering blood levels of affected medications
- Antacids and Acid-Reducing Medications: May cause premature dissolution of enteric-coated peppermint oil capsules, releasing oil in the stomach and causing heartburn. Take at least 2 hours apart
- Calcium Channel Blockers: Theoretical interaction due to peppermint’s calcium channel blocking effects, though clinical significance is unclear
- Sedatives and Central Nervous System Depressants: Peppermint may have mild sedative properties; theoretically could enhance effects of sedating medications, though evidence is limited
Other Considerations: In rare cases, peppermint oil can cause anal burning, especially with diarrhoea-predominant IBS. Some individuals may experience nausea or headache. Contact dermatitis is possible with repeated topical application. Always perform a patch test before using topically for the first time.
Scientific Evidence
Irritable Bowel Syndrome (IBS): Multiple systematic reviews and meta-analyses provide strong evidence for peppermint oil in IBS treatment. A 2019 meta-analysis of 12 randomised controlled trials (835 patients) found peppermint oil significantly improved global IBS symptoms with a risk ratio of 2.39 (95% CI: 1.93-2.97), meaning patients on peppermint oil were 2.4 times more likely to experience symptom improvement compared to placebo. Individual trials show 40-75% of patients achieve significant symptom reduction (≥50% improvement from baseline) compared to 24-38% with placebo. Effects are rapid, with improvement noted within 24 hours in some studies, and sustained over 4-week treatment periods. A novel sustained-release formulation (IBgard) demonstrated 40% reduction in Total IBS Symptom Score versus 24% with placebo. Peppermint oil is effective for IBS-D (diarrhea-predominant), IBS-M (mixed), and to a lesser extent IBS-C (constipation-predominant). Number needed to treat ranges from 2-3, comparable to prescription IBS medications.
Functional Dyspepsia and Indigestion: Studies show peppermint oil combined with caraway oil significantly improves symptoms of functional dyspepsia (upper abdominal discomfort, bloating, early satiety). Peppermint oil affects gastroduodenal motility and may help normalise delayed gastric emptying. The carminative effects reduce gas and bloating quickly and effectively.
Antimicrobial Activity: In vitro studies confirm peppermint essential oil has broad-spectrum antimicrobial activity. Minimum inhibitory concentrations (MICs) for common pathogens range from 0.3-5 mg/mL, with Candida albicans (MIC 0.3-0.6 mg/mL) and Staphylococcus epidermidis (MIC 0.6 mg/mL) being particularly sensitive. The oil is effective against E. coli, Pseudomonas aeruginosa, Salmonella species, Staphylococcus aureus, Streptococcus species, and fungi. The antimicrobial action results from cell membrane disruption and metabolic interference by menthol, menthone, and other volatile compounds.
Cognitive Function and Alertness: Multiple studies show peppermint aromatherapy improves memory performance, enhances alertness, and reduces mental fatigue. Effects include improved reaction time, enhanced working memory, and increased sustained attention. Mechanisms involve olfactory stimulation of brain regions involved in arousal and cognition.
Tension Headache Relief: Clinical trials demonstrate topical application of 10% peppermint oil solution to the forehead and temples significantly reduces tension headache pain, with effects comparable to 1000 mg acetaminophen. The cooling sensation from TRPM8 activation and local analgesic effects provide relief within 15-30 minutes.
Antioxidant and Anti-inflammatory: Laboratory studies confirm strong antioxidant activity correlated with rosmarinic acid and total phenolic content. Peppermint extracts inhibit inflammatory cytokine production (TNF-α, IL-6) and show anti-inflammatory effects in animal models of inflammation. Eriocitrin demonstrates particularly potent antioxidant effects.
Western Energetics
Temperature: Cooling. Peppermint is one of the most cooling herbs available, addressing “hot” conditions including digestive heat, inflammation, fever, and hot flashes. The intense cooling effect makes it suitable for any condition with heat excess
Moisture: Drying to Neutral. The astringent tannins and aromatic oils have some drying properties, though less pronounced than many aromatic herbs. The tea can be slightly drying to mucous membranes, but general effects are relatively balanced
Tissue State: Primarily indicated for Heat/Excitation (inflammation, spasm, irritation, tension) and Damp/Heat combinations (hot, inflamed digestive conditions with gas and bloating). The cooling, antispasmodic nature makes it ideal for “hot” spasmodic conditions–cramping with heat and irritation
Taste
Pungent: The dominant aromatic, penetrating quality from menthol and other volatile oils. This pungency moves energy, stimulates circulation, and opens channels. Supports expectorant and carminative actions
Cooling/Sweet: The characteristic cooling sensation is not truly a taste but a neurological response to menthol. However, peppermint does have an underlying sweet quality that is nourishing and soothing. This sweetness balances the pungency
Slightly Bitter: A subtle bitterness from phenolic compounds supports digestive stimulation and liver function, though this is mild compared to the cooling pungency
Plant Lore
In Greek mythology, the nymph Minthe (also spelled Menthe) was beloved by Hades, god of the underworld. When Persephone discovered the affair, she transformed Minthe into a lowly plant that would be trodden underfoot. Hades, unable to reverse the transformation, gave the plant its distinctive and pleasing scent so that Minthe’s sweetness would rise up whenever someone walked upon her. The genus name Mentha honors this story.
The ancient Greeks and Romans used mint extensively, rubbing it on tables before feasts to welcome guests and weaving it into crowns worn at banquets, believing it prevented intoxication and stimulated the mind. Roman naturalist Pliny wrote extensively about mint’s many uses, declaring that “the very smell of it alone recovers and refreshes the spirit.” Romans also used it to flavor sauces and wines, as a strewing herb to freshen rooms and repel vermin, and medicinally for digestive complaints and headaches.
In medieval Europe, mint was one of the essential strewing herbs scattered on floors to mask odors and discourage insects and rodents. It symbolised hospitality, and bunches of fresh mint were offered to guests as a welcoming gesture. Mint was also believed to have magical properties–it was hung in homes to protect against evil spirits and included in love spells and charms.
The medicinal use of mint spans millennia across cultures. Ancient Egyptian medical texts reference mint, and it was found in Egyptian tombs. Traditional Chinese medicine uses mint (particularly related species) to clear heat and benefit the throat and eyes. Ayurvedic medicine uses mint species for digestive disorders and respiratory conditions.
The intense cultivation and commercialisation of peppermint for its oil began in the 19th century, first in England and later extensively in the United States (particularly in Oregon, Washington, and the Midwest), where it became a major cash crop. Today, peppermint oil is one of the most widely used essential oils globally, found in pharmaceuticals, oral care products, cosmetics, foods, and beverages.
Additional Information
Peppermint vs. Spearmint: Peppermint (M. × piperita) contains high levels of menthol (30-55%) and is more potent medicinally, best for acute digestive spasms, pain, and intense cooling. Spearmint (M. spicata) contains primarily carvone (60-70%) with minimal menthol, providing a milder, sweeter flavor and gentler action. Spearmint is better for children, for long-term use, when a less pungent flavor is desired, and for people sensitive to menthol’s intensity. Both have therapeutic value, but peppermint has stronger clinical evidence and more powerful effects.
Chemotype Variation: Peppermint can have different chemotypes depending on genetics and growing conditions. The most common is the menthol-dominant chemotype, but variants exist with higher menthone, pulegone-menthol, or linalool content. Commercial therapeutic peppermint oil should be high in menthol (>30%) for optimal medicinal effects.
Enteric-Coating Technology: Modern enteric-coated peppermint oil capsules use sophisticated delivery systems including multi-layered coatings that resist stomach acid but dissolve in the alkaline environment of the small intestine (pH 5.5-6.5). Some advanced formulations use sustained-release microsphere technology (SST) that releases oil gradually over 4 hours in the small intestine, maximising therapeutic effects while minimising side effects. This technology makes peppermint oil effective for IBS where older formulations showed variable results.
Gut-Brain Axis Herb: Peppermint is considered a premier herb for conditions involving the gut-brain axis–digestive issues triggered or worsened by stress, anxiety, or psychological factors. The combination of direct antispasmodic effects on the gut with aromatic effects on the nervous system makes it particularly valuable for stress-related digestive complaints.
The Cooling “Illusion”: The cooling sensation from menthol is sometimes called a “phantom taste” or “phantom cold”–it’s a neurological phenomenon where TRPM8 receptors are activated by menthol’s binding, creating the perception of cold without actual temperature change. This same mechanism allows menthol to provide pain relief through temperature-sensing pathway modulation.
Cultivation for Home Use: Peppermint is one of the easiest medicinal herbs to grow, though its aggressive spreading requires management. Grow in large pots or with buried barriers to contain runners. Harvest frequently to prevent flowering and maintain tender leaf production. Fresh leaves can be used in tea, frozen for later use, or dried in bunches or dehydrators. Homegrown peppermint is excellent for culinary and simple medicinal teas, though therapeutic essential oil requires specialised distillation equipment.
New Zealand Availability: Peppermint grows vigorously in New Zealand’s temperate climate and is widely available in gardens, naturalised in moist areas, and sold at garden centers. Fresh peppermint leaves are available year-round from gardens or can be purchased from farmers markets. Dried peppermint leaf tea is available from supermarkets, health stores, and bulk herb suppliers. Peppermint essential oil is widely available from health stores and aromatherapy suppliers. Enteric-coated peppermint oil capsules for IBS are available from pharmacies.
Sources
Alammar, N., Wang, L., Saberi, B., Nanavati, J., Holtmann, G., Shinohara, R. T., & Mullin, G. E. (2019). The impact of peppermint oil on the irritable bowel syndrome: A meta-analysis of the pooled clinical data. BMC Complementary and Alternative Medicine, 19(1), 21.
Cash, B. D., Epstein, M. S., & Shah, S. M. (2016). A novel delivery system of peppermint oil is an effective therapy for irritable bowel syndrome symptoms. Digestive Diseases and Sciences, 61(2), 560–571.
Cappello, G., Spezzaferro, M., Grossi, L., Manzoli, L., & Marzio, L. (2007). Peppermint oil (Mintoil®) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial. Digestive and Liver Disease, 39(6), 530–536.
Gruľová, D., De Martino, L., Mancini, E., Tkáčiková, Ľ., Šalamon, I., Fejer, J., & De Feo, V. (2021). Chemical composition and antimicrobial properties of Mentha × piperita cv. ‘Kristinka’ essential oil. Plants, 10(8), 1558.
Hawthorn, M., Ferrante, J., Luchowski, E., Rutledge, A., Wei, X. Y., & Triggle, D. J. (1988). The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations. Alimentary Pharmacology & Therapeutics, 2(2), 101–118.
Khanna, R., MacDonald, J. K., & Levesque, B. G. (2014). Peppermint oil for the treatment of irritable bowel syndrome: A systematic review and meta-analysis. Journal of Clinical Gastroenterology, 48(6), 505–512.
Liu, B., Fan, L., Balakrishna, S., Sui, A., Morris, J. B., & Jordt, S. E. (2013). TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain, 154(10), 2169–2177.
McKemy, D. D., Neuhausser, W. M., & Julius, D. (2002). Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature, 416(6876), 52–58.
Micklefield, G. H., Redeker, Y., Meister, V., Jung, O., Greving, I., & May, B. (2003). Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytotherapy Research, 17(6), 701–703.
Niu, Y., Wang, T., Liu, S., Yuan, H., Li, W., Fu, L., & Liu, J. (2020). Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel. Nature Communications, 11, 3790.
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., & Patapoutian, A. (2002). A TRP channel that senses cold stimuli and menthol. Cell, 108(5), 705–715.
Schuhmacher, A., Reichling, J., & Schnitzler, P. (2003). Virucidal effect of peppermint oil on the enveloped viruses herpes simplex virus type 1 and type 2 in vitro. Phytomedicine, 10(6-7), 504–510.
Shen, Y., Debellard, M. E., Salzer, J. L., Moskovitz, J., & Ivanova, S. (2017). Cellular and molecular targets of menthol actions. Frontiers in Neurology, 8, 472.
Szőke, É., Bálint, M., Hetényi, C., Marquez, V. E., Zimmer, A., Högyes, E., Sándor, Z., Király, K., Matyus, P., Bölcskei, K., Tóth, A., & Szolcsányi, J. (2018). Effects of menthol on capsaicin-sensitive thermoreceptor and nociceptor neurons. Acta Physiologica Hungarica, 105(4), 419-430.
Weerts, Z. Z. R. M., Masclee, A. A. M., Witteman, B. J. M., Clemens, C. H. M., Winkens, B., Brouwers, J. R. B. J., Frijlink, H. W., Muris, J. W. M., De Wit, N. J., Essers, B. A. B., Tack, J., Snijkers, J. T. W., Bours, A. M. H., de Ruiter-van der Ploeg, A. S., Jonkers, D. M. A. E., & Keszthelyi, D. (2020). Efficacy and safety of peppermint oil in a randomized, double-blind trial of patients with irritable bowel syndrome. Gastroenterology, 158(1), 123–136.
Yousuf, P. M. H., Noba, N., Shohel, M., Bhattacherjee, R., & Das, B. K. (2013). Mentha piperita L.: Essential oil and extracts, their biological activities, and perspectives on the development of new medicinal and cosmetic products. Molecules, 28(21), 7245.
Disclaimer: This monograph is for educational purposes only and is not medical advice. Please consult with a qualified healthcare practitioner before using any herbal remedy, especially if you are pregnant, nursing, taking medication, or have a known medical condition. Do not use peppermint products on or near the face of infants or young children. If you have gallstones, bile duct obstruction, severe GERD, or are taking cyclosporine, consult your healthcare provider before use.

